Symbol
Name
ID

Cdh2
cadherin 2
MGI:88355

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Agenesis of corpus callosum

Interhypothalamic adhesion

Interhemispheric cyst

Periventricular heterotopia

Anxiety

Auditory hallucination

Autistic behavior

Attention deficit hyperactivity disorder

Impulsivity

Self-injurious behavior

Intellectual disability

Bimanual synkinesia

Global developmental delay

Delayed fine motor development

Delayed gross motor development

Focal impaired awareness seizure

Infantile spasms

Disease(s) Associated with CDH2

agenesis of corpus callosum, cardiac, ocular, and genital syndrome

Mouse Phenotypes

abnormal radial glial cell morphology

abnormal neuronal migration

wavy neural tube

abnormal brain development

abnormal cortical ventricular zone morphology

abnormal cerebral cortex morphology

abnormal neocortex morphology

thickened cerebral cortex

abnormal nervous system tract morphology

decreased dopaminergic neuron number

increased neuronal precursor cell number

abnormal synapse morphology

abnormal synaptic vesicle number

ectopic neuron

abnormal spinal cord morphology

abnormal spinal cord motor column morphology

abnormal synaptic vesicle clustering

abnormal synaptic vesicle recycling

abnormal sensorimotor gating

impaired synaptic plasticity

decreased miniature excitatory postsynaptic current frequency

abnormal prepulse inhibition

decreased neurotransmitter release

Availability

Mouse Genotype

Cdh2^em1Obir/Cdh2^em1Obir

Cdh2^{Gt(OST49160)Lex}/Cdh2^{Gt(OST49160)Lex}

Cdh2^tm1Hyn/Cdh2^tm1Hyn

Cdh2^tm1Glr/Cdh2^tm1Glr
Olig2^tm1(cre)Tmj/Olig2⁺ (conditional)

Cdh2^tm1Glr/Cdh2^tm1Glr
Emx1^tm1(cre)Krj/Emx1⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23